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ALQEMI EXO-AD

Revolutionize your skincare routine with EXO-AD, a groundbreaking freeze-dried exosome powder derived from ethically sourced human adipose stem cells. Designed to boost regeneration, reduce inflammation, and support your skin’s protective barrier, this powerful formula is the ultimate companion for micro-infusion or daily skincare. Tested and validated on an NS300 the industry standard.

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What Makes it Magical
  • 95% Exosome Concentration: Features an industry-leading 11 billion particles per vial for unmatched skin regeneration and repair.
  • Cutting-Edge Cell-to-Cell Communication: Exosomes carry proteins, growth factors, and cytokines that instruct your skin to heal, rejuvenate, and rebuild.
  • Customizable Use: Mix with your favorite serum, cream, or saline for daily hydration or advanced micro-infusion treatments.
  • Accelerates Skin Healing: Ideal for post-treatment recovery or addressing scars and inflammation.
How to Use

Option 1: During Micro-Infusion Treatments

  1. Add up to 4ml of distilled water, saline, or an applicable serum to the EXO-AD vial.
  2. Shake well to dissolve and use with the ALQEMI Micro Infusion Suite for targeted delivery into the epidermis.
  3. Gently stamp onto the skin, covering the desired area.
  4. Refrigerate remaining product, use within 72 hours.

Option 2: As a Custom Serum

  1. Blend EXO-AD powder into 1oz of your favorite serum or cream.
  2. Shake thoroughly to ensure full dissolution and store in a beauty fridge.
  3. Apply as part of your daily skincare routine for ongoing hydration, repair, and protection.
Perfect For
  • Enhancing the effects of micro-infusion and collagen induction therapy.
  • Rejuvenating aging skin with elasticity loss, wrinkles, or chronic redness.
  • Accelerating post-treatment recovery from chemical peels, lasers, or IPL.
  • Strengthening the skin barrier and improving hydration levels.
  • Evening out skin tone and reducing hyperpigmentation.
Key Ingredient
  • Human Adipocyte Conditioned Media (95% Exosomes): Provides over 150 growth factors and proteins, delivering targeted cellular regeneration.
Product Details
Package Contains

3 x 300mg of EXO-AD ( 900mg total ).

Ingredients

Human Adipocyte Conditioned Media, Mannitol. *Mannitol is used to create the powder and is necessary.

Product Care

Unopened and opened product requires refrigeration

EXPIRATION DATES

Unopened bottle : 2 year shelf life.

Needling:

Opened bottle. Refrigerate. Use within 72 hours OR mix into a serum with preservatives. Discard unused product after expiration.

Daily Topical Use: (Mixed Elixir)

Use mixed elixir (w/ preservative) within 3 months refrigerated.
Mix EXO-AD into another daily serum or cream with preservatives such as Regenerate, Nano Hyaluronic and Dr. Platinum Potions for prolonged use*.

*Mandatory refrigeration of serums and creams if combined with EXO-AD Exosomes.

Cold Shipping Notice
Limitations

Refrigerated products ship on mondays, tuesdays, and wednesdays.

Platinum Skin Care As Seen In

Platinum Skin Care featured in
Platinum Skin Care featured in
ALQEMI EXO-AD closeup of open box

Alqemi EXO-AD

It’s Like Programming Your Skin to Heal

Imagine having the ability to tell your skin exactly how to heal, rejuvenate, and thrive. That’s what EXO-AD does. Powered by cutting-edge exosome technology, it delivers precise cellular instructions to boost collagen, reduce inflammation, and repair your skin’s barrier. Whether you’re addressing signs of aging, recovering post-treatment, or seeking everyday hydration, EXO-AD gives your skin the tools it needs to transform from the inside out.

A glowing cell icon or a molecular structure to signify cellular regeneration

Stimulates Cellular Repair

Flame with a line through it icon

Calms Inflammation

Beaker with mixing lines icon

Barrier Support and Hydration

Beaker with mixing lines

Customizable Use

Meet Alqemi EXO-AD

Revolutionize your skincare routine with EXO-AD, a groundbreaking freeze-dried exosome powder derived from ethically sourced human adipose stem cells. Designed to boost regeneration, reduce inflammation, and support your skin’s protective barrier, this powerful formula is the ultimate companion for micro-infusion or daily skincare.

  • Precise Cellular Repair: Sends powerful signals to your cells to repair damage and boost collagen production.
  • Calms Inflammation: Reduces redness and irritation, promoting a calm, balanced complexion.
  • Boosts Hydration and Elasticity: Strengthens your skin’s barrier, locking in moisture for a plump, youthful look.
  • Enhances Results with Micro-Infusion: Perfectly complements the ALQEMI Micro Infusion Suite for targeted delivery.
  • Customizable for Your Routine: Easily mix into your favorite serums or use on its own for versatile skin care.

Built for Safety – Tested, Certified, and Backed by 17+ Years of Research

When I say EXO-AD is safe, I’m not just saying it. I’m showing you why you can trust this to go on your skin—especially if you’re sensitive, post-peel, or healing from microneedling.

We don’t cut corners here. Over 17 years of scientific research has gone into these exosomes and we’re proud knowing they follow some of the strictest safety and stem cell testing standards in the world.

Here's What Sets EXO-AD Apart:

Safety Icon

Medical-Grade Safety from Start to Finish

Test tube Icon

Human Cell Culture Medium Safety Tests

No Animals Used Icons

Zero Serum. Zero Animal Products.

Documentation Icon

From Lab to Skin: Fully Documented and Transparent

Medical-Grade Safety From Start to Finish

Safety tested for:  HBV, HCV, HIV, HTLV, CMV, EBV, Parvovirus B19, TB, Syphilis, Chlamydia, Neisseria, and more​.

Test tubes with orange caps arranged on a white surface.

All cell materials are handled under cleanroom conditions: Class 1B (ISO 10,000 or better)​.

Complies with FDA-equivalent safety standards from the Ministry of Food and Drug Safety​

Isolation and Preservation of Adipose-Derived Stem Cells

Adipose Tissue Harvest

Adipose Tissue
Harvest

Virus & Microbial testing of adipose tissue donors

Virus & Microbial testing of adipose tissue donors

Isolation of adipose-deprived stem cells

Isolation of adipose-deprived
stem cells

Storage / Thawing of Adiposed-derived stem cells

Storage / 
Thawing of Adiposed-derived stem cells

Human Cell Culture Medium Safety Tests (all passed):

  • Primary skin irritation
  • Sensitization
  • Photo toxicity
  • Genotoxicity
  • Human patch testing​
  • Safety Standard & Requirement

Zero Serum. Zero Animal Products.

We use a proprietary, serum-free medium—no animal components, ever.

Cultured in hypoxic conditions with Vitamin A, B, C, and glutamine modulation to induce over 150+ growth factors and exosomes​Stem cell cultivation t…​human stem cell.

5 Stages

A process that induces a large number of growth factors from stem cells 

ABIOS’s Patented technology – Step 1 isolation of adispose-derived Stem cells – Step 2 Seed Culture / Main Culture – Step 3 Serum free culture – Step 4 Recovery / Filtration – Step 5 Formulation
ABIOS’s Patented technology – Step 1 isolation of adispose-derived Stem cells – Step 2 Seed Culture / Main Culture – Step 3 Serum free culture – Step 4 Recovery / Filtration – Step 5 Formulation

From Lab to Skin: Fully Documented and Transparent

Every step is recorded, tested, and batch-tracked:

Manufacturing Hygiene: Quarterly monitoring + SOPs for contamination control

Raw Material Traceability: From donor to vial, we track every step

Stability & Purity Testing: Mycoplasma, sterility, absence of source cells and serum—all verified​

Results of In vitro analysis

After Lyophilzaiion (0 week - 8 week)

Table showing call representation with various parameters and results.
Table showing call representation with various parameters and results.

Cycle: Storage temperature was cycled between 40C and 450C at 12-hour intervals

Cycle: Storage temperature was cycled between 40C and 450C at 12-hour intervals


Table displaying categories and results over different time periods.
Table displaying categories and results over different time periods.

Cycle: Storage temperature was cycled between 40C and 450C at 12-hour intervals

Cycle: Storage temperature was cycled between 40C and 450C at 12-hour intervals

Freeze-Dried the Right Way - Why EXO-AD Lasts (and the Others Don't)

There’s been some buzz lately trying to scare people away from freeze-dried exosomes. And yes—if they’re made wrong, that fear is totally valid.
But EXO-AD? We don’t play guessing games with your skin.

Here’s the truth:

✅ What Makes EXO-AD Different?

We protect every single exosome in EXO-AD using a pharmaceutical-grade cryoprotectant called Mannitol. You’ll even see it in our short, clean ingredient list.

That protection acts like a soft bubble wrap around each exosome during freeze-drying—keeping their structure, benefits, and healing power totally intact.

And we don’t just say this. We proved it by testing on an NS300 the industry standard.

❌ The Problem with Most Freeze-Dried Exosomes

When exosomes are freeze-dried without protection, they can get shredded by ice crystals. Think of it like freezing a balloon filled with water—it’ll pop.


That’s what damages the lipid bilayer (the outer shell), and ruins the exosome’s ability to do anything helpful for your skin.

This is exactly what that upcoming Harvard-affiliated study found. But what they don’t mention? They tested unprotected exosomes. Not ours.

Proof That EXO-AD is Built to Last

Here’s what the science (and our lab results) show:

Graphs comparing data before and after lyophilization.

Structure Stays Intact

Before and after freeze-drying, exosome size and particle count remained stable.

  • No clumping
  • No degradtion
  • 100% ready to get to work on your skin
Exosome marker analysis before and after lyophilization, showing varying intensities.

Surface Markers Stay Strong

Every EXO-AD vial is full of real, functional exosomes. How do we know? Because key markers like CD81, ALIX, FLOT1, and ICAM1 were all fully preserved after freeze-drying. That means you’re getting the real deal, not an empty shell.

Clear vial containing white powder labeled

Safe for Weeks-Even with Temperature Swings

In an 8-week stress test, our lyophilized exosomes were stored from 4°C to 45°C (39°F  to 114°F), simulating real-world shipping and storage.



  • Regenerative effects maintained under refrigerated conditions
  • No toxicity detected at any point
  • Stable and safe long after opening

Backed by
Published Research

A 2018 study in the International Journal of Pharmaceutics confirmed that properly freeze-dried exosomes with cryoprotectants (like Mannitol or Trehalose):

  • Keep their structure, RNA, and proteins
  • Work just as well as fresh or frozen exosomes
  • 
Stay active for 4+ weeks at room temp Preservation of exosome…

“Trehalose prevented damage… structure and activity were preserved…
lyophilized exosomes remained safe and effective.Ӊ۬

IJ Pharmaceutics, 2018

Why This Matters for Your Skin

Close-up of a brown eye with long eyelashes and soft skin around it.

You don’t need a $2,000 refrigerated vial or some miracle lab in LA.
You need something that’s:

  • Scientifically safe
  • Actually works

  •  Scientifically safe
  • And is built for real, everyday people


That’s exactly what we made EXO-AD for.

Results &

Transformations

Social Proof

Confident Skin Starts Here

Cutting Edge

Proven Ingredients

Infographic of Alqemi exo-ad with high-quality exosome skincare
infographic-of-alqemi-exo-ad-with-exosome-skincare-information

Powered by Cutting-Edge Science

Human Adipocyte Conditioned Media (95% Exosomes)


Provides over 150 growth factors and proteins, delivering targeted cellular regeneration.

Benefits

Who it’s For / What It’s For

ALQEMI EXO-AD person adding EXO-AD to the needle applicator

Boost Skin Renewal from Within


Transmit powerful signals to your cells, enhancing collagen synthesis and improving elasticity. 

alquemi exo ad overview product with complementary products to boost skin regeneration

Calm and Soothe Your Skin

Minimize redness, irritation, and chronic inflammation for a balanced complexion.


opening ALQEMI EXO-AD with freeze-dried exosome skincare powder

Lock in Moisture, Protect Your Skin

Improves lipid levels and hydration, restoring the skin’s barrier function.

ALQEMI EXO-AD closeup of open box

The Ultimate Skincare Add-On

Mix with your favorite serum, saline, or distilled water for versatile use.

Know Your Options

Us Vs Them

Why Choose the Alqemi EXO-AD

Alqemi exo-ad with high-quality exosome skincare from platinum skin care Other brand exo-ad exosome skincare

Feature

EXO-AD (Us)

Typical EXO-AD (Them)

Exosome Concentration

95% pure, 11 billion particles per vial.

10–25% exosome concentration, diluted.

Customizable Use

Easily mix with serums or use for needling.

Limited application methods.

Safety and Purity

Ethically sourced, rigorously tested, no DNA.

Often unclear origins or testing.

Barrier Repair Benefits

Strengthens lipid levels and hydrates deeply.

Minimal impact on barrier function.

Other brand exo-ad exosome skincare

Typical EXO-AD (Them)

  • 10–25% exosome concentration, diluted.
  • Limited application methods.
  • Often unclear origins or testing.
  • Minimal impact on barrier function.

Step-By-Step

How to Use

Part 1: Using with Micro-Infusion

ALQEMI EXO-AD Person adding a solution to the needle applicator miniature

Prepare the Solution

  • Add up to 4ml of saline solution, EXO-serum or any other serum into the EXO-AD vial.
  • Shake to dissolve and refrigerate any remainder for up to 72 hours. 
alqemi exo ad product overview with alqemi micro infusion

Micro-Infusion Application

  • Use the solution with the ALQEMI Micro Infusion device, following its usage guidelines.
  • Gently stamp into the skin for maximum absorption.

Part 2: Mixing with Other Serums or Topical Use

adding regenerate growth factor serum to the alqemi exo-ad vial

Customize Your Serum

  • Blend EXO-AD powder into a 1oz serum or cream of your choice with preservatives. Use up to 3 months refrigerated.
  • You may also chose to use part of EXO-AD at a time. Simply add some powder into the container of your product of choice.
daily routine

Daily Application

  • Apply directly to clean skin as part of your skincare regimen.
  • Layer with moisturizer and SPF for daytime protection.

The Finer

Details

EXO-AD Lyophilized powder 95% (11 billion particles/vial)

One of the first freeze-dried pure* Human Adipose Exosome powders available on the market today. Mix it with what YOU want to create a daily serum, cream or micro-infusion elixir to needle with! 

Groundbreaking Exosome Technology for your skin's regeneration, aging, and photoaging needs. 

EXO-AD is a pure Exosome derived from ethically sourced human adipose stem cells. Exosomes do not have a nucleus or DNA and cannot replicate. Instead, they carry proteins, growth factors, cytokines and amino acids to help beautify the skin when Micro Infused or applied topically. 

Recommended uses: 

  • During needling processes at home or professionally.
  • Aging skin with wrinkles
    Targeting post care (peels, microneedle/collagen induction therapy, fractional lasers and LED therapies).
  • Effective in reducing excess inflammatory response. 
    Enhancing the protective barrier of the skin.
  • Can aid in the collagen synthesis cycle. 
    Optimizing natural turnover cycles for healthier skin and hair. 
    Helping to reduce chronic redness in the skin from inflammation.
  • Skin hydration. Lipids and proteins can help to improve moisture levels.
  • Melanin regulation can aid in evening the skin's tone.
    Increased skin elasticity.

Exosomes = Cell to Cell communication. This is cutting edge! Exosomes are transmitters that send information from cell to cell - basically telling it what to do. Their message is clear:

  1. Activate the body's natural healing capabilities. 

  2. Reduce the signs of aging.

  3. Reduce inflammation.

  4. Stimulate collagen and elastin.

  5. Regenerate

  6. Regenerate.

  7. Regenerate!

When they are applied to the skin, or needled into the skin, they are able to pass along their messages/proteins/growth factors to the recipient cells. 

Stem cells posses an ability to hone-in and find damaged areas within our bodily organs and tissues. During this process, stem cells secrete various proteins like cytokines, chemokines, growth factors, angiogenic factors ... and Exosomes. These proteins work together to regenerate the damaged areas. This effect is called the Paracrine Effect. In a nutshell, this "cell signaling" induces changes in nearby sells that stimulate cell growth! 

AAPE contains over 150 types of growth factor proteins and exosomes that enhance this effect. 

EXO-AD states that it has 95% exosomes. Is that a high amount? Oh yes! Other exosome serums that you might find out there most likely have a content of around 10 or up to 25%. Ours far exceeds this. The exosome concentration is more than 1.2 x 10 (10th power) particles/vial. 

The answer is easy - and of course is the best one = humans. 

NO! This does not come from a baby, or umbilical cords. Please rest your minds.

Exosomes are naturally occurring though, and must be extracted from some sort of body tissue. This is ethically sourced from human adipose tissues that were safely and legally donated. KFDA human cell and tissue culture media safety standards fully equipped within EXotractionTM patented technology. There are over 29 patents in this technology with over 17 years of product manufacturing.

Cleanroom grade of the cell processing/cultivation facility is Class 1B (Class 10,000) or higher. So where this is created is very safe. Other safety concerns might be regarding human DNA? There is no DNA present in an exosome AAPE. Only the naturally secreted proteins are collected with the exosomes. All cellular debris is eliminated. There are many rigorous tests that are performed for the safety of use. Exosomes are non-immunogenic and SAFE as topical treatments.

How do I use this if it is a powder? 

This will need to be incorporated INTO another serum or saline solution. Please avoid acids or any very low pH products.

USAGE OPTION 1: EXO-AD powder can be blended with your favorite 1oz. serum and used as a daily product. Simple to mix. Add a small amount of your serum into the powder and shake to dissolve. Pour into final container, shake fully and store in Beauty Fridge. *Do NOT mix with acids.

OPTION 2: For a concentrated infusion, add up to 4ml of Distilled water, Saline Solution or another applicable serum into the EXO-AD bottle. Shake and allow the powder to dissolve. Use immediately, refrigerate the remainder. If you are needling, you will use most of this at the time of treatment, but may have some left for the next few days during healing.

Yes! A 12-week study was conducted to evaluate the effectiveness of combining HACS (human adipose tissue stem cell-derived exosome-containing solution) and microneedling to treat facial skin aging - including: Overall skin improvement, wrinkles, elasticity, skin hydration, skin pigmentation, and collagen/elastin histopathologic evaluation. The study was approved by the Institutional Review Board and followed ethical guidelines. Participants provided consent and received three treatment sessions, spaced three weeks apart, with a six-week follow-up. During each session, HACS and microneedling were applied to one side of the face, while the other side received microneedling with saline as a control. Treatments were randomly assigned to each side of the face.

Twenty-eight participants, all over 40 years old, were enrolled. The sample size was determined based on feasibility. Exclusion criteria included pregnancy, keloid scarring, and active skin conditions, and participants were not allowed to use other treatments like resurfacing or fillers during the study.

This study demonstrated that combined treatment with HACS application and microneedling is effective for facial skin aging. Based on the results obtained from clinical evaluation, objective measurement of various skin aging signs, and microscopic evaluation of histological changes, this combined therapy exhibited higher efficacy than that of microneedling alone. Furthermore, combining both methods was a safe treatment with tolerable side effect profiles. By the 12 week visit, 46% of the participants had an Improved status, 14% had Much Improved status, and 7% had Very Much Improved status over the standard needling with only a saline solution![2] So much benefit when adding on the EXO-AD to your needling program. 

Solar radiation, also known as UV, UVA, UVB and UVR. These are various ultraviolet radiation wavelengths from the sun. UV exposure is the major source of extrinsic skin aging, which is also known as photoaging. 

Photoaging accounts for nearly 80% of facial aging! This is why daily SPF is so important. 

It is characterized by fine wrinkles, dryness, laxity, rough texture, decreased elasticity, impaired wound healing, and benign and malignant growths.[1] In the 12 week study referenced above, the melanin index significantly decreased on the HACS side from baseline to week 12. The average decrease was 9.9%.[2]

As skin ages, its protective barrier weakens and recovers more slowly after damage. The levels of important lipids, like ceramides, decrease in the outer skin layer, leading to reduced secretion of protective lipid structures. This loss of ceramides is a key factor in the weakened skin barrier. Restoring ceramide levels could help improve this barrier. 

Additionally, ASCEs (skin exosomes) stimulate the production of genes that support the skin barrier and lipid metabolism, including the creation of new ceramides. This promotes the formation of protective structures in the skin, reduces water loss, improves skin hydration, and restores the skin's barrier function. Therefore, ASCEs likely contribute to the observed improvements in skin hydration.

  • Ingredients:  Human Adipocyte Conditioned Media, Mannitol. 300mg (3g) bottles (3 count). *Mannitol is used to create the powder and is necessary.
  • Best used within 2 years. Use opened bottles within 6 months. Cold storage.

Source:

1. Application of adipose-derived stem cells in photoaging: basic science and literature review

2. Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study

What is It?

EXO-AD Lyophilized powder 95% (11 billion particles/vial)

One of the first freeze-dried pure* Human Adipose Exosome powders available on the market today. Mix it with what YOU want to create a daily serum, cream or micro-infusion elixir to needle with! 

Ground Breaking Exosome Technology for your skin's regeneration, aging, and photoaging needs. 

EXO-AD is a pure Exosome derived from ethically sourced human adipose stem cells. Exosomes do not have a nucleus or DNA and cannot replicate. Instead, they carry proteins, growth factors, cytokines and amino acids to help beautify the skin when Micro Infused or applied topically. 

Recommended uses: 

  • During needling processes at home or professionally.
  • Aging skin with wrinkles
    Targeting post care (peels, microneedle/collagen induction therapy, fractional lasers and LED therapies.
  • Effective in reducing excess inflammatory response. 
    Enhancing the protective barrier of the skin.
  • Can aid in the collagen synthesis cycle. 
    Optimizing natural turnover cycles for healthier skin and hair. 
    Helping to reduce chronic redness in the skin from inflammation.
  • Skin hydration. Lipids and proteins can help to improve moisture levels.
  • Melanin regulation can aid in evening the skin's tone.
    Increased skin elasticity.

What are Exosomes?

Exosomes = Cell to Cell communication. This is cutting edge! Exosomes are transmitters that send information from cell to cell - basically telling it what to do. Their message is clear:

  1. Activate the bodies natural healing capabilities and

  2. Reduce the signs of aging.

  3. Reduce inflammation.

  4. Stimulate collagen and elastin.

  5. Regenerate

  6. Regenerate.

  7. Regenerate!

When they are applied to the skin, or needled into the skin, they are able to pass along their messages/proteins/growth factors to the recipient cells. 

Stem cells posses an ability to hone-in and find damaged areas within our bodily organs and tissues. During this process, stem cells secrete various proteins like cytokines, chemokines, growth factors, angiogenic factors ... and Exosomes. These proteins work together to regenerate the damaged areas. This effect is called the Paracrine Effect. In a nutshell, this "cell signaling" induces changes in nearby sells that stimulate cell growth! 

AAPE contains over 150 types of growth factor proteins and exosomes that enhance this effect. 

EXO-AD states that it has 95% exosomes. Is that a high amount? Oh yes! Other exosome serums that you might find out there most likely have a content of around 10 or up to 25%. Ours far exceeds this. The exosome concentration is more than 1.2 x 10 (10th power) particles/vial. 

 

Where do Human adipose Exosomes come from?

The answer is easy - and of course is the best one = humans. 

NO! This does not come from a baby, or umbilical cords. Please rest your minds.

Exosomes are naturally occurring though, and must be extracted from some sort of body tissue. This is ethically sourced from human adipose tissues that were safely and legally donated. KFDA human cell and tissue culture media safety standards fully equipped within EXotractionTM patented technology. There are over 29 patents in this technology with over 17 years of product manufacturing.

 

Is This Safe?

Cleanroom grade of the cell processing/cultivation facility is Class 1B (Class 10,000) or higher. So where this is created is very safe. Other safety concerns might be regarding human DNA? There is not DNA present in an exosome AAPE. Only the naturally secreted proteins are collected with the exosomes. All cellular debris is eliminated. There are many rigorous tests that are performed for the safety of use. Exosomes are non-immunogenic and SAFE as topical treatments.

 

Use Cases

How do I use this if it is a powder? 

This will need to be incorporated INTO another serum or saline solution for needling. Refrigerate and use within 72 hours - or, mix remainder INTO a product with preservatives and use for 2-3 months refrigerated.  Please avoid acids or any very low pH products.

USAGE OPTION 1: EXO-AD powder can be blended with your favorite 1oz. serum and used as a daily product. Simple to mix. Add a small amount of your serum into the powder and shake gently, or stir some EXO-AD into your product of choice. Shake fully and store in Beauty Fridge. *Do NOT mix with acids.

OPTION 2: For a concentrated needling infusion, add up to 4ml of Distilled water, Saline Solution or another applicable serum into the EXO-AD bottle. Shake and allow the powder to dissolve. Use within 72 hours, refrigerate the remainder. If you are needling, you will use most of this at the time of treatment, but may have some left for the next 1-2 days during healing.

Are there advantages to needling with EXO-AD?

Yes! A 12-week study was conducted to evaluate the effectiveness of combining HACS (human adipose tissue stem cell-derived exosome-containing solution) and microneedling to treat facial skin aging - including: Overall skin improvement, wrinkles, elasticity, skin hydration, skin pigmentation, and collagen/elastin histopathologic evaluation . The study was approved by the Institutional Review Board and followed ethical guidelines. Participants provided consent and received three treatment sessions, spaced three weeks apart, with a six-week follow-up. During each session, HACS and microneedling were applied to one side of the face, while the other side received microneedling with saline as a control. Treatments were randomly assigned to each side of the face.

Twenty-eight participants, all over 40 years old, were enrolled. The sample size was determined based on feasibility. Exclusion criteria included pregnancy, keloid scarring, and active skin conditions, and participants were not allowed to use other treatments like resurfacing or fillers during the study.

This study demonstrated that combined treatment with HACS application and microneedling is effective for facial skin aging. Based on the results obtained from clinical evaluation, objective measurement of various skin aging signs, and microscopic evaluation of histological changes, this combined therapy exhibited higher efficacy than that of microneedling alone. Furthermore, combining both methods was a safe treatment with tolerable side effect profiles. By the 12 week visit, 46% of the participants had an Improved status, 14% had Much Improved status, and 7% had Very Much Improved status over the standard needling with only a saline solution![2] So much benefit when adding on the EXO-AD to your needling program. 

What is photoaging?

Solar radiation, also known as UV, UVA, UVB and UVR. These are various ultraviolet radiation wavelengths from the sun. UV exposure is the major source of extrinsic skin aging, which is also known as photoaging. 

Photoaging accounts for nearly 80% of facial aging! This is why daily SPF is so important. 

It is characterized by fine wrinkles, dryness, laxity, rough texture, decreased elasticity, impaired wound healing, and benign and malignant growths.[1] In the 12 week study referenced above, the melanin index significantly decreased on the HACS side from baseline to week 12. The average decrease was 9.9%.[2]

 

How can EXO-AD help with my skin's barrier?

As skin ages, its protective barrier weakens and recovers more slowly after damage. The levels of important lipids, like ceramides, decrease in the outer skin layer, leading to reduced secretion of protective lipid structures. This loss of ceramides is a key factor in the weakened skin barrier. Restoring ceramide levels could help improve this barrier. 

Additionally, ASCEs (skin exosomes) stimulate the production of genes that support the skin barrier and lipid metabolism, including the creation of new ceramides. This promotes the formation of protective structures in the skin, reduces water loss, improves skin hydration, and restores the skin's barrier function. Therefore, ASCEs likely contribute to the observed improvements in skin hydration.

Ingredients & Sources

 

  • Ingredients: Mannitol, Human Adipocyte Conditioned Media. 300mg (3g) bottles (3 count). *Mannitol is used to create the powder and is necessary.
  • Best used within 2 years. Use opened bottles within 6 months. Cold storage.

Source:

1. Application of adipose-derived stem cells in photoaging: basic science and literature review

2. Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study

Why Platinum

Who we are

Who we are


Skincare experts with decades of experience, we’re passionate about helping you achieve your best skin yet with professional-grade products trusted by clinics and skincare enthusiasts alike.

Our Mission

Our Mission


Empowering your skin transformation by bringing professional-quality skincare into your home with products and guidance that put you in control of your results.

Our Promise to You

Our Promise to You


Your skin’s safety is our priority. Every product is pH-calibrated, thoroughly tested, and backed by detailed instructions, so you can peel with confidence.

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FAQ's

When is the best time to use exosomes in my regimen?

Exosomes are especially beneficial before/during/or after needling sessions. They can also be used on any skin that is inflamed or irritated - such as after a peel or laser session, IPL. Many uses. They can also be used on a daily basis, or as needed for healthy skin. 

One of the most powerful ways to utilize an exosome's properties is to use it during a Collagen Induction Therapy/Micro-infusion session. The impact is multi-faceted and synergistic. The exosomes and 150+ growth factors and proteins, can penetrate deeply into the skin through the channels created during the process. Our ALQEMI Micro Infusion Suite is the perfect tool to use with our EXO-AD.

What is exosome therapy?

Using exosomes in therapeutic practices. Microneedling is one of the best, and most obvious choices, as it can allow the exosomes to penetrate deeper into the skin to stimulate renewal on multiple layers of tissue. This can make the exosomes more efficient than in just a topical application.

Can I shake the exosomes without damaging them? 

In general, light physical actions such as shaking the bottle by hand, or gently tapping it, do not affect the integrity of exosomes. They are inherently designed to withstand various physical stimuli while maintaining their structure and function.

Movements such as mild shaking during transportation, light tapping, rotating the bottle, or gentle mixing by the user, does not cause any damage to the exosomes’ structure or biological function.

*Nanoparticle tracking analysis (NTA) conducted after shipping via ground transit with couriers consistently shows normal particle size and concentration without any issues.

Please avoid the following actions:

  • Strong vortexing (e.g., vigorous mixing for more than 5 seconds)
  • Sonication (ultrasonic treatment)
  • High-speed mechanical stirring

These types of physical stress could potentially disrupt the lipid bilayer of exosomes or alter their contents such as proteins and miRNAs. Such intense conditions are typically limited to experimental laboratory settings and are extremely unlikely to occur during regular packing, transportation, or customer usage.

Does this contain preservatives?

No. This is the pure frozen exosomes for your use. Your dilutant will contain a preservative most likely though.

Does this need to stay frozen or cold?

EXO-AD needs to remain cold for best use. It will be ok up to 10 days during shipping, but should immediately be cooled when it arrives. Global orders must choose an express method to purchase this.  It is stored in a deep freezer at our facility for freshness. Once it arrives at your home, please refrigerate or freeze the box immediately. We have countertop Beauty Refrigerators for ease of use. See those here

What is a lyophilized powder?

Lyophilization, also known as freeze-drying, is where water is removed from a frozen substance by sublimation, leaving behind a dry powder that can be easily reconstituted when needed; essentially, it's a stable, dehydrated form of a substance that can be stored for long periods and then rehydrated by adding liquid.

What is Human Adipocyte Conditioned Media 95%?

Trade Name: AAPE. INCI Name: Human Adipocyte Conditioned Media Extract. AAPE is a mixture of refined growth factors extracted from human adipose-derived stem cell conditioned media. It is used to induce collagen synthesis in dermal cells to maximize the revitalizing effects of skin regeneration. 

Can you use this on skin that has rosacea?

Yes, there are no contraindications and it could be beneficial.

Can you use this on acne prone skin?

Yes, there are no contraindications and it could be beneficial. 

Can you use this on eczema on the face or body?

Yes, there are no contraindications and it could be beneficial. 

Can I use this with my Regenerate EGF Stem Cell Serum?

Yes, our Regenerate has many growth factors and would be a wonderful base for your EXO-AD serum to be mixed into. 

Can I mix this with acids like: Vitamin C, Tretinoin, Serum 15 or Serum 30?

No, we do not suggest mixing this with an acid. 

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