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  • SYN(R)-AKE,  new, anti-wrinkle active,  synthetic tripeptide, venom of the Temple Viper, smoothes mimic wrinkles, 50% compound, strongest neuropeptide, neuro peptide, slow muscle contractions over time, botox alternative, injection alternatives,
  • Syn-Ake, SynAke temple viper venom alternative. 50% strength. High strength botox alternative.
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  • botox alternative, synake peptide,
  • Directions Dr. Platinum Potions Synake
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Synake Complex 50


Product Description

SYN(R)-AKE Complex 50% Age Killing Effect

You are purchasing a vial of pure Syn-Ake peptide mixed only with a penetration enhancer! This is not your "average" face serum. Pure, super potent actives like this are not available as a singular ingredient. You CAN use this full strength, or mix it into your favorite creams and serums. You will receive:

Syn-Ake 50% Botox Alternative
  • One - 2 dram* (1/4oz) amber glass dropper bottle of Syn-Ake. *You may choose a larger size.
  • Direction sheet for mixing
SYN®-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity. SYN®-AKE smoothes mimic wrinkles in a short period. Age killing effect particularly effective against expression lines. Intensive anti-wrinkles care.

SYN(R)-AKE peptide reduces muscle cell contraction and its action is reversible. You have the option to apply your actives directly into any product that you currently have or mix into our Formulating Cream. *Dare we suggest adding these actives into our Derma Snap 8L or GABA creams - which are both already teaming with penetration enhancers and other proven actives????

SYN(R)-AKE has been thoroughly tested and is considered to be appropriate for cosmetic applications.


  • Antagonist of the muscle nicotinic acetylcholine receptor (mnAChR)
  • Blocks Na+ uptake at the post-synaptic membrane
  • Inhibits muscle contractions

Each active will come in a 7.5ml glass amber bottle with a dropper for ease of usage. The percentage of actives is very high, and will only be mixed with 2 penetrating actives and a preserving ingredient. Our Neuro-Peptide-Actives are SUPER CHARGED to allow deep penetration into your skin.

SYN(R)-AKE is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. PENTAPHARM *(Syn-ake's manufacturer) has developed, over the past 30 years, a unique approach for the breeding and housing of venomous snakes and particularly the Brazilian Lance Adder Bothrops moojeni whose venom is used for therapeutic (anticoagulants, haemostatics) and diagnostic products. Currently, some 10, 000 specimens of this snake species are bred and housed at PENTAPHARM DO BRASIL, making PENTAPHARM the largest snake breeder and keeper in the world. The long experience of PENTAPHARM in snake venom research has made possible the investigation of venom' peptides for cosmetic applications. A special focus has been the investigation of the Temple Viper's venom.

SYN(R)-AKE acts in a manner similar to that of Waglerin 1 which acts at the post-synaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane's receptor (mnAChR). As the muscular nicotinic ACh receptors are blocked, the ion canal remains closed. There is no uptake of Na+ and the muscles stay relaxed. Source: McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein& JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor. J. Pharmacol. Exp. Therap.


SYN(R)-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity. SYN(R)-AKE smoothes mimic wrinkles in a short period.

Cosmetic applications

  • Age killing effect particularly effective against expression lines
  • Intensive anti-wrinkles care

Suggested concentration:1-4% *Our formulation is a 5% (per 3 drops). 

INCI Name:Glycerine, Water, Dipeptide Diaminobutyroyl Benzylamide Diacetate

Efficacy Tests- in vitro tests:The efficacy of the SYN(R)-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.

Synake Concentration Graph

In vivo tests:The measurement of the smoothing and anti-wrinkle effect of SYN(R)-AKE (4%) was compared to a placebo. A cream was applied to the forehead twice daily during 28 days.

SynN(R)-AKE - Age Killing Effect.The smoothing effect (Ra) was measured on 80% of thevolunteers and the anti-wrinkle effect (Rz, Rt) measuredon 73% of the volunteers. Results showed up to -52% of wrinkle size after28 days application!

synake smoothing anti-wrinkle

Copyright 2014 (C) Platinum Skin Care ~ All Rights Reserved


SEE detailed direction sheets in product photos (top of page). Apply this powerful elixir to your problem areas 2x daily before all other serums or creams. Expect to see noticable changes within 30-45 days.


*SYN-AKE : Deionized Water, Glycerine, *Dipeptide Diaminobutyroyl, Benzylamide Diacetate, Gynostemma Pentaphylum, Panax Ginseng Root Extract, Ethoxydiglycol, Polysorbate 20, Benzyl Alcohol ( BA is natural anti-microbial, NOT a drying or grain alcohol), Methylisothiazolinone.

Product Reviews

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  1. poor packaging 5 5 Stars

    Posted by on

    i recieved the product last night but the serum is leaking of the bottle, i haven't use it yet, but i hope the packaging could be improve..

  2. I have been using Synake 5 5 Stars

    Posted by on

    I have been using Synake 50 for more than a year and the reason why I keep ordering it is because I think is superior. Thank u

  3. Synake 50 is incredibly good 5 5 Stars

    Posted by on

    Synake 50 is incredibly good

  4. I love Synake 50 it 5 5 Stars

    Posted by on

    I love Synake 50 it is really good thank u

  5. Hi this is Marie Ruiz, 5 5 Stars

    Posted by on

    Hi this is Marie Ruiz, I love Synake complex 50 and also do my clients who use it, business is a little slow right now but I like very much the product, but I would like it more if it were stronger, Thank you, Marie

  6. I'm don't think that o 2 5 Stars

    Posted by on

    I'm don't think that o am seeing results...yet. I will continue to use.

  7. SYNAKE 5 5 Stars

    Posted by on

    I really saw a difference the first week I used it. I have very dry skin with a few deep wrinkles. They were less visible with this. Unfortunately I dropped the bottle on a tile floor and broke it. I suggest changing to a plastic bottle if possible.

  8. BEAUTY SECRET!! 5 5 Stars

    Posted by on

    This product is in 150.00 creams with less potency than here. I've been using synake for about 2 years and I feel I look five years younger than I am (combined with peels and copper). You have to be careful not to put it above your brow bone or your lids will droop. No it's not botox but that's a good thing. Topical muscle relaxer. Now I can feel its effects even when I haven't put it on becasue I've used it for so long.. LOVE IT!

  9. FANTASTIC 5 5 Stars

    Posted by on

    I bought this product after being tired of paying higher prices at the shops for products with lesser amounts of Synake. And i am sooo glad i did! I use Gaba in the morn followed by a serum with 3 drops of this product, and at night i simply use a moisturiser into which ive mixed half a bottle of Synake into, and the results have truly been nothing short of amazing. Previously, people had long accused me of using botox as i try to take care of myself,( i dont use botox!) now even i can see why they say that more than ever, the change has been that good. What a combo, Synake and Gaba!!!!!!

  10. BIG LIKE! 5 5 Stars

    Posted by on

    I have been ordering from Plat skin care for years & continue to be happy with the products:) I ordered this a week ago & like the "feel" of it & think I am starting to see "tightness" (maybe wishful thinking). Is it ok to empty the bottle into the GABA cream? Would this dilute it too much? **[Platinum comment][ absolutely not. If you put the entire bottle into your *slightly used-- you need to make some head-room for the Synake* GABA bottle you will end up with a stronger-than-recommended-dosage...That's perfect in our book]. Or, change the effectiveness? Also, thanks for making the bottles smaller [shorter/wider]. The only negative thing I can say (minor) about the products is the packaging in the past couple yrs. Nicer, but too much "packaging." I travel w/these products & the bigger, "fancy" tops, bottles, etc. take up room. The products, however, are fantastic.

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